The plague of Justinian or Justinianic plague (AD 541–549) was an epidemic of plague that afflicted the entire Mediterranean Basin, Europe, and the Near East, especially the Sasanian Empire and the Byzantine Empire. The plague is named for the Byzantine Emperor Justinian I (r. 527–565) who, according to his court historian Procopius, contracted the disease and recovered in 542, at the height of the epidemic which killed about a fifth of the population in the imperial capital Constantinople. The contagion arrived in Roman Egypt in 541, spread around the Mediterranean Sea until 544, and persisted in Northern Europe and the Arabian Peninsula until 549. By 543, the plague had spread to every corner of Justinian's empire.

The plague's severity and impact remain debated. Some scholars assert that as the first episode of the first plague pandemic, it had profound economic, social, and political effects across Europe and the Near East and cultural and religious impact on Eastern Roman society. Other scholars such as Mordechai and Eisenberg have argued that the Plague of Justinian was overstated by primary sources and, while it would have been incredibly impactful on a personal level, did not have a severe or even a long lasting impact on the population of the Mediterranean in the Age of Justinian. These claims have been criticised for their methodology and handling of sources.

In 2013, researchers confirmed earlier speculation that the cause of the plague of Justinian was Yersinia p

Why this event still matters

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